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KMID : 0363320170380060980
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Journal of Korean Oriental Internal Medicine
2017 Volume.38 No. 6 p.980 ~ p.999
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Systematic Review of Clinical Research on Daegunjoong-tang for Improvement of Gastrointestinal Motility after Surgery for Gastrointestinal Cancer
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Han Ga-Jin
Seong Shin
Kim Sung-Su
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Abstract
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Objectives: This study aimed to evaluate the efficacy of Daegunjoong-tang for improvement of gastrointestinal motility after surgery due to gastrointestinal cancer by analyzing the existing clinical research.
Methods: Clinical studies about Daegunjoong-tang for improvement of gastrointestinal motility after surgery due to gastrointestinal cancer were identified in a literature search using the search term “Daikenchuto AND cancer AND ileus.” The studies were analyzed in terms of design, inclusion and exclusion of participants, intervention, control, outcomes, and results.
Results: Nine articles were identified in the literature search. Four trials included colon cancer participants with colectomy, and three studies included gastric cancer with total gastrectomy. The intervention in each case was Daegunjoong-tang, and most interventions were made by a pharmaceutical company with a Good Manufacturing Practice facility. The most frequently used control was a placebo. The methods were diverse, including measuring gastrointestinal function, motility, quality of life, symptom scores with a numeric rating scale, and blood tests. Safety was investigated by recording adverse events.
Conclusions: Some issues were discovered by reviewing the existing clinical research about Daegunjoong-tang for improvement of gastrointestinal motility after surgery for gastrointestinal cancer. These results will be utilized as evidence for using Daegunjoong-tang in clinical practice and designing a clinical trial for Korean patients.
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KEYWORD
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Daegunjoong-tang (Daikenchuto), cancer, surgery, gastrointestinal motility, clinical research
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